Co vše lze zjistit ze slin?


Jako hudba budoucnosti vypadají nejnovější výsledky výzkumu slin. Ty totiž naznačují, že místo rozboru krve nám bude prováděn rozbor slin a výsledky budou k dispozici na PC? Nevěříte?

Již několik let se rozbor slin ukazuje jako velice slibný zdroj informací o celkovém zdraví organizmu. Rozbor slin je totiž výhodný z mnoha důvodů. Pro odběr vzorku není třeba žádných vpichů jehlou, je tedy bezbolestný. Odběr nevyžaduje odbornou zručnost a může být proveden v klidu domova.

Sliny jsou v centru zájmu nového diagnostického trendu zvaného salivaomika (v angl. salivaomics), neboli nauka o slinách. V dubnu tohoto roku odstartovala Americká společnost pro dentální výzkum nový projekt nazvaný „Vědecká základna pro salivaomiku“ (Salivaomics Knowledge Base – SKB), který poskytuje informace rozboru slin dobrovolníků. V databázi je v současnosti 1166 různých proteinů a biomarkerů, podle kterých se dají rozpoznat nejrůznější patologické procesy v našem organizmu. Databáze se neustále rozšiřuje o nové biomarkery. Možná již brzy tedy budeme své zdraví kontrolovat podle rozboru slin na svém PC prostřednictvím internetu.



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Status: Otevřená všem
Počet příspěvků:     103955

Co vše lze zjistit ze slin?


Jako hudba budoucnosti vypadají nejnovější výsledky výzkumu slin. Ty totiž naznačují, že místo rozboru krve nám bude prováděn rozbor slin a výsledky budou k dispozici na PC? Nevěříte?

Již několik let se rozbor slin ukazuje jako velice slibný zdroj informací o celkovém zdraví organizmu. Rozbor slin je totiž výhodný z mnoha důvodů. Pro odběr vzorku není třeba žádných vpichů jehlou, je tedy bezbolestný. Odběr nevyžaduje odbornou zručnost a může být proveden v klidu domova.

Sliny jsou v centru zájmu nového diagnostického trendu zvaného salivaomika (v angl. salivaomics), neboli nauka o slinách. V dubnu tohoto roku odstartovala Americká společnost pro dentální výzkum nový projekt nazvaný „Vědecká základna pro salivaomiku“ (Salivaomics Knowledge Base – SKB), který poskytuje informace rozboru slin dobrovolníků. V databázi je v současnosti 1166 různých proteinů a biomarkerů, podle kterých se dají rozpoznat nejrůznější patologické procesy v našem organizmu. Databáze se neustále rozšiřuje o nové biomarkery. Možná již brzy tedy budeme své zdraví kontrolovat podle rozboru slin na svém PC prostřednictvím internetu.

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Josephcrofe 03:13 12.01.2025
The survivors of recent crashes were sitting at the back of the plane. What does that tell us about airplane safety?
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Look at the photos of the two fatal air crashes of the last two weeks, and amid the horror and the anguish, one thought might come to mind for frequent flyers.

The old frequent-flyer adage is that sitting at the back of the plane is a safer place to be than at the front — and the wreckage of both Azerbaijan Airlines flight 8243 and Jeju Air flight 2216 seem to bear that out.
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The 29 survivors of the Azeri crash were all sitting at the back of the plane, which split into two, leaving the rear half largely intact. The sole survivors of the South Korean crash, meanwhile, were the two flight attendants in their jumpseats in the very tail of the plane.

So is that old adage — and the dark humor jokes about first and business class seats being good until there’s a problem with the plane — right after all?

In 2015, TIME Magazine reporters wrote that they had combed through the records of all US plane crashes with both fatalities and survivors from 1985 to 2000, and found in a meta-analysis that seats in the back third of the aircraft had a 32% fatality rate overall, compared with 38% in the front third and 39% in the middle third.

Even better, they found, were middle seats in that back third of the cabin, with a 28% fatality rate. The “worst” seats were aisles in the middle third of the aircraft, with a 44% fatality rate.
But does that still hold true in 2024?

According to aviation safety experts, it’s an old wives’ tale.

“There isn’t any data that shows a correlation of seating to survivability,” says Hassan Shahidi, president of the Flight Safety Foundation. “Every accident is different.”

“If we’re talking about a fatal crash, then there is almost no difference where one sits,” says Cheng-Lung Wu, associate professor at the School of Aviation of the University of New South Wales, Sydney.

Ed Galea, professor of fire safety engineering at London’s University of Greenwich, who has conducted landmark studies on plane crash evacuations, warns, “There is no magic safest seat.”


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Most plane crashes are ‘survivable’
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First, the good news. “The vast majority of aircraft accidents are survivable, and the majority of people in accidents survive,” says Galea. Since 1988, aircraft — and the seats inside them — must be built to withstand an impact of up to 16G, or g-force up to 16 times the force of gravity. That means, he says, that in most incidents, “it’s possible to survive the trauma of the impact of the crash.”

For instance, he classes the initial Jeju Air incident as survivable — an assumed bird strike, engine loss and belly landing on the runway, without functioning landing gear. “Had it not smashed into the concrete reinforced obstacle at the end of the runway, it’s quite possible the majority, if not everyone, could have survived,” he says.

The Azerbaijan Airlines crash, on the other hand, he classes as a non-survivable accident, and calls it a “miracle” that anyone made it out alive.
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Most aircraft involved in accidents, however, are not — as suspicion is growing over the Azerbaijan crash — shot out of the sky.

And with modern planes built to withstand impacts and slow the spread of fire, Galea puts the chances of surviving a “survivable” accident at at least 90%.

Instead, he says, what makes the difference between life and death in most modern accidents is how fast passengers can evacuate.

Aircraft today must show that they can be evacuated in 90 seconds in order to gain certification. But a theoretical evacuation — practiced with volunteers at the manufacturers’ premises — is very different from the reality of a panicked public onboard a jet that has just crash-landed.
Galea, an evacuation expert, has conducted research for the UK’s Civil Aviation Authority (CAA) looking at the most “survivable” seats on a plane. His landmark research, conducted over several years in the early 2000s, looked at how passengers and crew behaved during a post-crash evacuation, rather than looking at the crashes themselves. By compiling data from 1,917 passengers and 155 crew involved in 105 accidents from 1977 to 1999, his team created a database of human behavior around plane crashes.

His analysis of which exits passengers actually used “shattered many myths about aircraft evacuation,” he says. “Prior to my study, it was believed that passengers tend to use their boarding exit because it was the most familiar, and that passengers tend to go forward. My analysis of the data demonstrated that none of these myths were supported by the evidence.”


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JoshuaJes 02:50 12.01.2025
What New Glenn will do
In some ways, New Glenn has already made its mark on the launch industry. Blue Origin has for years pitched the rocket to compete with both SpaceX and United Launch Alliance — a joint venture of Boeing and Lockheed Martin that buys engines from Blue Origin — for lucrative military launch contracts.
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The US Space Force selected Blue Origin, ULA and SpaceX in June to compete for $5.6 billion worth of Pentagon contracts for national security missions slated to launch over the next four years.
Blue Origin also has deals with several commercial companies to launch satellites. The contracts include plans to help deploy Amazon’s Kuiper internet satellites and a recently inked deal with AST SpaceMobile to help launch the Midland, Texas-based company’s space-based cellular broadband network.

New Glenn could also be instrumental in building Blue Origin’s planned space station, called Orbital Reef. Blue Origin and it commercial partners, including Sierra Space and Boeing, among others, hope the station will one day provide a new destination for astronauts as the International Space Station is phased out of service.
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New Glenn vs. other powerful rockets
New Glenn packs significant power. Dubbed a “heavy-lift” vehicle, its capabilities lie between SpaceX’s Falcon 9 rocket and the more powerful Falcon Heavy launch vehicle.

SpaceX’s workhorse Falcon 9, for example, can haul up to 22.8 metric tons (50,265 pounds) to space. While New Glenn is capable of carrying about double that mass, it may also be roughly the same price as a Falcon 9: reportedly around $60 million to $70 million per launch.

“I think in order to compete with Falcon 9, you have to go head-to-head or better on price,” said Caleb Henry, the director of research at Quilty Space, which provides data and analysis about the space sector.

The question, however, is whether Blue Origin will be able to sustain a competitive price point, Henry added.

Still, one feature that makes New Glenn stand out is its large payload fairing, or nose cone. The component protects the cargo bay and is a whopping 23 feet (7 meters) wide — nearly 6 feet (2 meters) larger than that of SpaceX’s Falcon 9 or Falcon Heavy.

Henry said Blue Origin likely opted to outfit New Glenn with such a large fairing in order to help fulfill Bezos’ vision of the future.


WilliamKet 02:45 12.01.2025
What’s on board this flight
Blue Origin had planned to launch a pair of Mars-bound satellites on behalf of NASA for the first flight of New Glenn.

But delays with the rocket’s development prompted the space agency to change course, moving that flight to this spring at the earliest. So for this inaugural flight, Blue Origin opted to instead fly a “demonstrator” that will test technology needed for the company’s proposed Blue Ring spacecraft — which will aim to serve as a sort of in-space rideshare vehicle, dragging satellites deeper into space when needed.
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The demonstrator on this New Glenn flight will remain aboard the rocket for the entire six-hour flight, Blue Origin said, and it will validate “communications capabilities from orbit to ground” as well as “test its in-space telemetry, tracking and command hardware, and ground-based radiometric tracking.”

The Blue Ring Pathfinder demonstrator is part of a deal Blue Origin inked with the US Department of Defense’s Defense Innovation Unit.
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Why Blue Origin wants to reuse rockets
Similar to SpaceX, Blue Origin is aiming to recover and refly its first-stage rocket boosters in a bid to make launches less expensive.

“Reusability is integral to radically reducing cost-per-launch,” the company said in a recent news release, using the same oft-repeated sentiment that SpaceX has touted since it began landing rocket boosters in 2015.
Bezos, however, has acknowledged the importance of reusing rocket parts since he founded the company in 2000 — two years before Musk established SpaceX. And the company has already developed its suborbital New Shepard tourism rocket to be reusable.
“It’s not a copy cat game,” Henry said. “Blue Origin has been pursuing reusable vehicles since before reusable vehicles were cool. Now it’s much more of a mainstream idea (because of SpaceX). The difference is that it’s taken Blue Origin so much longer to get to orbit.”

If successful, returning the New Glenn rocket booster for a safe landing will be a stunning feat. After expending most of its fuel to propel the rocket’s upper stage to space, the first-stage booster will need to make a clean separation. The booster must then maneuver with pinpoint guidance and reignite its engines with precision timing to avoid crashing into the ocean or the Jacklyn recovery platform.


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